Description

tert-Butyl 2-(4-Iodophenyl)Acetate is a high-purity, versatile aryl acetic acid ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic combination of a protected carboxylic acid group and a reactive aryl iodide moiety, enabling efficient, multi-step synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for constructing complex molecules via cross-coupling reactions and subsequent deprotection.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs) containing biphenyl or substituted phenyl acetic acid cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the iodophenyl group acts as a handle for introducing diverse heterocyclic systems.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialized polymers and liquid crystals with tailored electronic properties.
• Cross-Coupling Reactions: The aryl iodide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to create complex biaryl and conjugated structures.
• Chemical Research & Development: A valuable reagent in medicinal chemistry for library synthesis and structure-activity relationship (SAR) studies due to its orthogonal reactivity.
• Protecting Group Strategy: The tert-butyl ester group provides a robust acid-labile protecting group for carboxylic acids, which can be cleanly removed under mild conditions in multi-step syntheses.

Basic Information

Product Name	tert-Butyl 2-(4-Iodophenyl)Acetate
CAS No.	856250-87-8
Molecular Formula	C12H15IO2
Molecular Weight	318.15 g/mol
Synonyms	2-(4-Iodophenyl)acetic acid tert-butyl ester; 4-Iodobenzeneacetic acid 1,1-dimethylethyl ester; tert-Butyl (4-iodophenyl)acetate; 1-tert-Butyl 2-(4-iodophenyl) acetate; Acetic acid, 2-(4-iodophenyl)-, 1,1-dimethylethyl ester; 856250-87-8; p-Iodophenylacetic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-Iodophenyl)Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines where applicable to support our customers in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.