Description

6-Chloro-5-Iodonicotinonitrile is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents on the pyridine ring, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring halogenated heterocyclic cores.
• Material Science Research: Acts as a precursor for functionalized ligands in catalysis and for creating novel organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl systems.
• Nucleophilic Substitution: The chloro group is reactive towards various nucleophiles, enabling further functionalization of the pyridine ring.
• Chemical Library Development: Employed in combinatorial and medicinal chemistry for the generation of diverse compound libraries for screening.

Basic Information

Product Name	6-Chloro-5-Iodonicotinonitrile
CAS No.	856213-95-1
Molecular Formula	C6H2ClIN2
Molecular Weight	264.45 g/mol
Synonyms	5-Iodo-6-chloropyridine-3-carbonitrile; 3-Cyano-5-iodo-6-chloropyridine; 6-Chloro-5-iodo-3-pyridinecarbonitrile; 6-Chloro-5-iodonicotinonitrile; 6-Chloro-5-iodo-3-cyanopyridine; 5-Iodo-6-chloro-3-cyanopyridine; 3-Pyridinecarbonitrile, 6-chloro-5-iodo-
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Iodonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.