Description

4-[5-Bromo-3-(Trifluoromethyl)Pyridin-2-Yl]Morpholine is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its core value lies in the strategic combination of a bromo-substituent and a trifluoromethyl group on a pyridine-morpholine scaffold, offering versatile reactivity for constructing complex molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) explorations to optimize the potency and pharmacokinetic properties of drug candidates.
• Fluorine Chemistry: The -CF3 group provides metabolic stability and lipophilicity, making it a valuable synthon in fluorine-based drug design.

Basic Information

Product Name	4-[5-Bromo-3-(Trifluoromethyl)Pyridin-2-Yl]Morpholine
CAS No.	856166-07-9
Molecular Formula	C10H10BrF3N2O
Molecular Weight	311.10 g/mol
Synonyms	2-Morpholino-5-bromo-3-(trifluoromethyl)pyridine; 5-Bromo-3-(trifluoromethyl)-2-morpholinopyridine; 4-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)morpholine; 856166-07-9; 2-Pyridinemethanol, 5-bromo-3-(trifluoromethyl)-, 4-morpholine derivative
EINECS	Contact for details

Quality Control

Our 4-[5-Bromo-3-(Trifluoromethyl)Pyridin-2-Yl]Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.