Description

5-Hydroxypyridine-2-Carboxylic Acid tert-Butyl Ester is a high-purity, protected heterocyclic carboxylic acid derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, leveraging its heterocyclic core.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies.
• Custom Synthesis Building Block: Provides a protected carboxylic acid and hydroxyl group for multi-step, convergent synthesis strategies.

Basic Information

Product Name	5-Hydroxypyridine-2-Carboxylic Acid tert-Butyl Ester
CAS No.	854607-40-2
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	tert-Butyl 5-hydroxypicolinate; 5-Hydroxy-2-pyridinecarboxylic acid 1,1-dimethylethyl ester; 2-Pyridinecarboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester; 5-Hydroxypicolinic acid tert-butyl ester; Picolinic acid, 5-hydroxy-, tert-butyl ester; 5-Hydroxy-pyridine-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxypyridine-2-Carboxylic Acid tert-Butyl Ester is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.