Description

1-((2-(Trimethylsilyl)Ethoxy)Methyl)-2-Bromo-1H-Imidazole-4-Carbonitrile is a high-value, multi-functional chemical intermediate featuring a bromo-imidazole core protected by a (2-(trimethylsilyl)ethoxy)methyl (SEM) group. This compound matters for its role as a versatile building block in complex organic synthesis, where its reactive bromine and nitrile groups allow for selective functionalization. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for potential drug candidates, especially kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the development of novel fungicides and herbicides, leveraging the imidazole scaffold for biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination.
• Nucleophilic Substitution: The SEM-protected imidazole nitrogen allows for selective deprotection and further modification at a later synthetic stage.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for biological screening.

Basic Information

Product Name	1-((2-(Trimethylsilyl)Ethoxy)Methyl)-2-Bromo-1H-Imidazole-4-Carbonitrile
CAS No.	854044-51-2
Molecular Formula	C11H18BrN3OSi
Molecular Weight	332.27 g/mol
Synonyms	2-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carbonitrile; 2-Bromo-1-SEM-imidazole-4-carbonitrile; 2-Bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-4-cyanoimidazole; 1H-Imidazole-4-carbonitrile, 2-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-; 2-Bromo-1-[(2-trimethylsilylethoxy)methyl]imidazole-4-carbonitrile; 854044-51-2; Br-SEM-Imidazole-CN
EINECS	Contact for details

Quality Control

Our 1-((2-(Trimethylsilyl)Ethoxy)Methyl)-2-Bromo-1H-Imidazole-4-Carbonitrile is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.