Description

1H-Benzimidazole, 2-[(S)-[(3-Methyl-4-Nitro-2-Pyridinyl)Methyl]Sulfinyl]- is a high-purity, chiral sulfoxide derivative of a benzimidazole-pyridine hybrid structure, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel, targeted therapeutic agents, particularly in the development of proton pump inhibitors and other specialized bioactive molecules. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating next-generation treatments for gastrointestinal and metabolic disorders.

Application

• Pharmaceutical Intermediate: Primary use as a chiral building block in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs), especially for gastrointestinal therapeutics.
• Proton Pump Inhibitor (PPI) Research: Core precursor in the development and optimization of novel, enantiomerically pure proton pump inhibitors for acid-related diseases.
• Medicinal Chemistry & Drug Discovery: Valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in medicinal chemistry programs targeting various enzymes and receptors.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its stable sulfoxide moiety, which can influence stereoselectivity in subsequent chemical transformations.
• Biochemical Research: Used as a reference standard or probe in biochemical assays to study enzyme inhibition and metabolic pathways.
• Fine Chemical Production: Serves as a specialized intermediate for contract manufacturing organizations (CMOs) producing cGMP materials for clinical trial supplies.

Basic Information

Product Name	1H-Benzimidazole, 2-[(S)-[(3-Methyl-4-Nitro-2-Pyridinyl)Methyl]Sulfinyl]-
CAS No.	853950-79-5
Molecular Formula	C14H12N4O3S
Molecular Weight	316.34 g/mol
Synonyms	(S)-2-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; Dexlansoprazole Related Compound; Dexlansoprazole Impurity; (S)-Omeprazole Sulfide Nitropyridine Derivative; TAK-390 Related Substance; Chiral Benzimidazole Sulfoxide; 1H-Benzimidazole, 2-[[(3-methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-, (S)-; Lanzoprazole Sulfenamide Nitropyridine Analog
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 2-[(S)-[(3-Methyl-4-Nitro-2-Pyridinyl)Methyl]Sulfinyl]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.