Description

2-[(R)-(3-Methyl-4-Nitropyridin-2-Yl)Methanesulfinyl]-1H-1,3-Benzodiazole is a high-purity, chiral organic compound featuring a benzimidazole core linked to a substituted nitropyridine via a sulfinyl bridge. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate (API intermediate) for the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery and development, particularly for projects targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for the design and development of new chemical entities, especially those targeting enzyme inhibition.
• Biochemical Research: Employed as a standard or reagent in studies investigating molecular interactions and binding affinities.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing production processes for candidate drugs.
• Asymmetric Synthesis: Leverages its chiral sulfinyl group for the construction of enantiomerically pure compounds.

Basic Information

Product Name	2-[(R)-(3-Methyl-4-Nitropyridin-2-Yl)Methanesulfinyl]-1H-1,3-Benzodiazole
CAS No.	853950-77-3
Molecular Formula	C₁₄H₁₂N₄O₃S
Molecular Weight	316.34 g/mol
Synonyms	(R)-2-[(3-Methyl-4-nitropyridin-2-yl)methanesulfinyl]-1H-benzimidazole; 2-[[(3-Methyl-4-nitro-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, (R)-; 853950-77-3; (R)-Lansoprazole Intermediate; (R)-Form of Lansoprazole Sulfoxide; AGN 190383 (related); Chiral Benzimidazole Sulfoxide Derivative
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.