Description

n-tert-Butoxycarbonyl-2-Fluoro-5-Methoxy-4-o-Methyl-L-Tyrosine Methyl Ester is a sophisticated, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical protected building block in the synthesis of complex peptides and peptidomimetics, enabling the exploration of novel therapeutic agents. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key protected precursor in the solid-phase and solution-phase synthesis of fluorinated and methoxylated peptide analogs for drug discovery.
• Peptidomimetic Development: Used to incorporate modified tyrosine residues into peptide backbones to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Protease Inhibitor Research: Serves as a building block for developing inhibitors targeting specific proteases, where the fluorine and methoxy substitutions are critical for activity.
• Radioligand and Tracer Synthesis: The fluorine atom provides a potential site for radiolabeling (e.g., with F-18) for use in Positron Emission Tomography (PET) imaging agent development.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes or labeled peptides to study enzyme function and protein-protein interactions.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) containing modified aromatic amino acids.

Basic Information

Product Name	n-tert-Butoxycarbonyl-2-Fluoro-5-Methoxy-4-o-Methyl-L-Tyrosine Methyl Ester
CAS No.	853759-49-6
Molecular Formula	C17H24FNO6
Molecular Weight	357.38 g/mol
Synonyms	Boc-2-F-5-MeO-4-OMe-L-Tyr-OMe; (2S)-3-(4-[(tert-Butoxy)carbonyl]-2-fluoro-5-methoxyphenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid methyl ester; Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(tert-butoxycarbonyl)-2-fluoro-5-methoxyphenyl]propanoate; Boc-L-Tyr(2-F-5-OMe-4-OMe)-OMe; N-Boc-2-Fluoro-5-methoxy-4-O-methyl-L-tyrosine methyl ester; Fmoc-L-Tyr(2-F-5-OMe-4-OMe)-OH (related Fmoc-protected form); 2-Fluoro-5-methoxy-4-O-methyl-L-tyrosine derivative
EINECS	Contact for details

Quality Control

Our production of n-tert-Butoxycarbonyl-2-Fluoro-5-Methoxy-4-o-Methyl-L-Tyrosine Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure high chemical and chiral purity, critical for sensitive pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.