Description

2-[(Difluoromethyl)Thio]Nicotinic Acid is a high-value, organosulfur nicotinic acid derivative characterized by its difluoromethylthio functional group. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring the difluoromethylthio moiety.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for catalytic systems.
• Material Science Research: Intermediate for synthesizing functionalized polymers or organic electronic materials.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes and bio-conjugation reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	2-[(Difluoromethyl)Thio]Nicotinic Acid
CAS No.	852706-16-2
Molecular Formula	C7H5F2NO2S
Molecular Weight	205.18 g/mol
Synonyms	2-[(Difluoromethyl)sulfanyl]pyridine-3-carboxylic acid; Nicotinic acid, 2-[(difluoromethyl)thio]-; 3-Pyridinecarboxylic acid, 2-[(difluoromethyl)thio]-; 2-(Difluoromethylthio)nicotinic acid; 852706-16-2; 2-[(Difluoromethyl)thio]pyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-[(Difluoromethyl)Thio]Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP, ISO, and REACH requirements for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.