Description

n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoroundecanoate is a highly reactive, perfluorinated N-hydroxysuccinimide (NHS) ester derivative designed for efficient bioconjugation and surface modification. This compound matters because it provides a robust and versatile linker for introducing long, stable perfluorocarbon chains onto biomolecules, imparting unique properties such as extreme hydrophobicity, chemical inertness, and potential for 19F-MRI applications. It is primarily needed by researchers and manufacturers in the fields of biopharmaceuticals, advanced materials science, and diagnostic imaging for labeling proteins, peptides, and other amine-containing substrates.

Application

• Bioconjugation Reagent: For the covalent attachment of perfluorocarbon (PFC) tags to primary amines on proteins, antibodies, peptides, and oligonucleotides to alter their physicochemical properties.
• 19F Magnetic Resonance Imaging (MRI) Tracer Development: Synthesis of targeted contrast agents for non-invasive molecular imaging and cell tracking due to the high natural abundance and sensitivity of the 19F nucleus.
• Surface Functionalization: Creating hydrophobic, fluorinated coatings on materials (e.g., glass, silicon, polymers) to impart oil- and water-repellent characteristics or to create specific biointerfaces.
• Fluorous Chemistry & Separation: Synthesis of fluorous-tagged molecules for use in fluorous solid-phase extraction (F-SPE) and fluorous liquid-liquid extraction to simplify purification processes.
• Proteomics & Biomarker Research: Labeling of amine groups in complex biological samples for mass spectrometry analysis or affinity purification strategies.
• Therapeutic Agent Modification: Conjugation to drug molecules or drug delivery vehicles (e.g., liposomes, nanoparticles) to enhance stability, alter pharmacokinetics, or enable imaging.
• Diagnostic Assay Development: Preparation of fluorinated probes and labels for use in immunoassays, biosensors, and other diagnostic platforms.

Basic Information

Product Name	n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoroundecanoate
CAS No.	852527-45-8
Molecular Formula	C₁₅H₈F₁₇NO₄
Molecular Weight	589.20 g/mol
Synonyms	NHS-Perfluoroundecanoate; Heptadecafluoroundecanoic Acid N-Hydroxysuccinimide Ester; 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoroundecanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; PFUA-NHS Ester; Perfluoroundecanoyloxy Succinimide; N-Succinimidyl Perfluoroundecanoate; 1-[(Perfluoroundecanoyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoroundecanoate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is characterized by NMR (¹H, ¹⁹F) and HPLC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store the product in a cool, dry place, ideally at 2-8°C or as indicated on the label. For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) in a desiccator to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.