Description

2-(4-Methyl-3-Phenylpiperazin-1-Yl)Nicotinaldehyde Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant synthetic interest. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced organic synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Academic & Institutional Research: Employed in universities and research institutes for studying heterocyclic chemistry and piperazine derivative reactivity.
• Process Development: Used in scaling up and optimizing synthetic routes for more complex molecules in pilot plants.

Basic Information

Product Name	2-(4-Methyl-3-Phenylpiperazin-1-Yl)Nicotinaldehyde Hydrochloride
CAS No.	852524-23-3
Molecular Formula	C17H19N3O · HCl
Molecular Weight	317.82 g/mol (Free base: 281.36 g/mol)
Synonyms	2-(4-Methyl-3-phenylpiperazin-1-yl)nicotinaldehyde hydrochloride; 2-(4-Methyl-3-phenyl-1-piperazinyl)-3-pyridinecarboxaldehyde hydrochloride; 3-Pyridinecarboxaldehyde, 2-(4-methyl-3-phenyl-1-piperazinyl)-, hydrochloride; Nicotinaldehyde, 2-(4-methyl-3-phenylpiperazino)-, hydrochloride; 852524-23-3; 2-(4-Methyl-3-phenylpiperazin-1-yl)pyridine-3-carbaldehyde HCl
EINECS	Contact for details

Quality Control

Our 2-(4-Methyl-3-Phenylpiperazin-1-Yl)Nicotinaldehyde Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.