Description

[[3-Cyano-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydropyridin-2-Yl]Thio]Acetic Acid is a high-value, multifunctional heterocyclic building block characterized by its pyridinone core, cyano group, and trifluoromethyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules targeting a range of therapeutic areas and crop protection solutions.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create tool compounds for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a precursor for functionalized polymers or organic electronic materials due to its electron-withdrawing groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	[[3-Cyano-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydropyridin-2-Yl]Thio]Acetic Acid
CAS No.	852388-81-9
Molecular Formula	C9H5F3N2O3S
Molecular Weight	278.21 g/mol
Synonyms	2-[[3-Cyano-6-oxo-4-(trifluoromethyl)-1,6-dihydro-2-pyridinyl]thio]acetic acid; (3-Cyano-6-oxo-4-trifluoromethyl-1,6-dihydro-2-pyridinylthio)acetic acid; 2-((3-Cyano-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-2-yl)thio)acetic acid; Acetic acid, [[3-cyano-6-oxo-4-(trifluoromethyl)-1,6-dihydro-2-pyridinyl]thio]-; 852388-81-9; 4-(Trifluoromethyl)-2-mercaptonicotinonitrile acetic acid derivative; TFMP derivative intermediate
EINECS	Contact for details

Quality Control

Our [[3-Cyano-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydropyridin-2-Yl]Thio]Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure consistent quality and batch-to-batch reproducibility. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.