Description

1-Piperidinecarboxylic Acid, 3-Hydroxy-4-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3R,4S)-Rel- CAS NO 852358-78-2 is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in its precise stereochemistry and functional groups, which are essential for constructing complex bioactive molecules with high enantiomeric purity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities in drug discovery pipelines.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Protease Inhibitor Development: The structural motif is relevant for the design and synthesis of inhibitors targeting specific proteases.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-up: Serves as a critical intermediate during the optimization and commercial scale-up of synthetic routes for target molecules.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Hydroxy-4-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3R,4S)-Rel-
CAS No.	852358-78-2
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(3R,4S)-rel-3-Hydroxy-4-(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3R,4S)-rel-3-hydroxy-4-(hydroxymethyl)piperidine-1-carboxylate; (3R,4S)-rel-1-Boc-3-hydroxy-4-(hydroxymethyl)piperidine; 1-Boc-3-hydroxy-4-hydroxymethylpiperidine (rel-(3R,4S)-); (rel-(3R,4S))-1-N-Boc-3-piperidinol-4-methanol; 1-(tert-Butoxycarbonyl)-3-hydroxy-4-(hydroxymethyl)piperidine (rel-(3R,4S)-); BOC-Pip(3-OH,4-CH2OH)-OH (rel)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) are available upon request, detailing purity, chiral purity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.