Description

S-Nicotine-5-Carboxaldehyde is a high-purity, advanced pharmaceutical intermediate and chiral building block. This compound is of significant value for the synthesis of novel nicotine analogs and other bioactive molecules, enabling research into new therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers focused on fine chemical synthesis and process development.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of novel nicotine receptor (nAChR) modulators and other pharmacologically active compounds.
• Agrochemical Research: Building block for developing new generation neonicotinoid analogs and other crop protection agents.
• Chemical Synthesis: Versatile aldehyde functionality for use in condensation, reductive amination, and other coupling reactions to create complex molecular architectures.
• Biochemical Research: Used in studies investigating nicotinic acetylcholine receptor structure, function, and ligand interactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	S-Nicotine-5-Carboxaldehyde
CAS No.	852238-97-2
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	(S)-Nicotine-5-carboxaldehyde; (S)-5-Formylnicotine; (S)-3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine-5-carbaldehyde; 5-Formyl-(S)-nicotine; Nicotine-5-carboxaldehyde (S-enantiomer); (S)-Pyridin-3-yl-5-carboxaldehyde-pyrrolidine; 5-Carboxaldehyde-(S)-nicotine
EINECS	Contact for details

Quality Control

Our S-Nicotine-5-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.