Description

2,5-Difluoro-4-Chloro Nicotinic Acid is a high-value, multi-functional halogenated nicotinic acid derivative. This compound serves as a critical building block in advanced organic synthesis, prized for its ability to introduce specific fluorine and chlorine substitutions into complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals with unique electronic or optical properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2,5-Difluoro-4-Chloro Nicotinic Acid
CAS No.	851386-42-0
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	4-Chloro-2,5-difluoronicotinic acid; 2,5-Difluoro-4-chloropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-chloro-2,5-difluoro-; Nicotinic acid, 4-chloro-2,5-difluoro-; 851386-42-0; 4-Chloro-2,5-difluoropyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Chloro Nicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.