Description

5,6-Difluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trimethylsilyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic materials, such as liquid crystals and electronic chemicals.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring fluorinated and silylated pyridine scaffolds.

Basic Information

Product Name	5,6-Difluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid
CAS No.	851386-37-3
Molecular Formula	C10H11F2NO2Si
Molecular Weight	243.28 g/mol
Synonyms	4-(Trimethylsilyl)-5,6-difluoropyridine-2-carboxylic acid; 5,6-Difluoro-4-(trimethylsilyl)picolinic acid; 2-Pyridinecarboxylic acid, 5,6-difluoro-4-(trimethylsilyl)-; 851386-37-3; 5,6-Difluoro-4-trimethylsilylpyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 5,6-Difluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.