Description

5,6-Difluoro Pyridine-3-Carboxylic Acid is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing the difluoropyridine moiety, a key structural feature that can significantly alter the physicochemical and biological properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty chemicals and materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoropyridine group enhances bioactivity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and electronic materials requiring fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical synthesis projects.
• Academic and Industrial R&D: Utilized in research laboratories for method development and exploring new chemical entities.

Basic Information

Product Name	5,6-Difluoro Pyridine-3-Carboxylic Acid
CAS No.	851386-33-9
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	3-Pyridinecarboxylic acid, 5,6-difluoro-; 5,6-Difluoronicotinic Acid; 5,6-Difluoro-3-pyridinecarboxylic Acid; 5,6-Difluoropyridine-3-carboxylic acid; Difluoropyridinecarboxylic Acid; 851386-33-9; 5,6-Difluoro-3-carboxypyridine
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.