Description

4-Chloro-5,6-Difluoropyridine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its core value lies in its unique halogenated pyridine scaffold, which serves as a critical precursor for constructing complex molecules with tailored biological and material properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a versatile precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom chemical synthesis services catering to R&D and pilot-scale production.

Basic Information

Product Name	4-Chloro-5,6-Difluoropyridine-3-Carboxylic Acid
CAS No.	851386-32-8
Molecular Formula	C6HClF2NO2
Molecular Weight	193.53 g/mol
Synonyms	3-Pyridinecarboxylic acid, 4-chloro-5,6-difluoro-; 4-Chloro-5,6-difluoronicotinic acid; 5,6-Difluoro-4-chloropyridine-3-carboxylic acid; 851386-32-8; 4-Chloro-5,6-difluoropyridine-3-carboxylic acid; Nicotinic acid, 4-chloro-5,6-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5,6-Difluoropyridine-3-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and LC-MS to verify identity, purity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.