Description

2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 1,1-Dimethylethyl Ester, Hydrochloride (1:1) is a high-purity, protected spirocyclic amine building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) due to its constrained spirocyclic and diaza structure, which can influence bioavailability and target binding.
• Peptidomimetic Synthesis: Serves as a core structure or a protected amino acid analog in the design of peptide-like molecules with enhanced stability.
• Ligand and Catalyst Development: Employed in the creation of novel chelating ligands or organocatalysts for asymmetric synthesis.
• Agrochemical Research: Used as an intermediate in the development of new herbicides, fungicides, or insecticides with novel modes of action.
• Chemical Biology Probe Synthesis: Incorporated into molecular probes for studying biological pathways and target identification.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 1,1-Dimethylethyl Ester, Hydrochloride (1:1)
CAS No.	851325-42-3
Molecular Formula	C13H25N2O2 • HCl
Molecular Weight	276.81 g/mol (Free base: 241.35 g/mol)
Synonyms	tert-Butyl 2,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride; 8-Boc-2,8-diazaspiro[4.5]decane hydrochloride; 2,8-Diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester hydrochloride; 8-(tert-Butoxycarbonyl)-2,8-diazaspiro[4.5]decane hydrochloride; Boc-2,8-diazaspiro[4.5]decane HCl; 1,1-Dimethylethyl 2,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride; 8-N-Boc-2,8-diazaspiro[4.5]decane hydrochloride
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, 1,1-Dimethylethyl Ester, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.