Description

6-Cyclopropyl-1-Isopropyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• API Synthesis: Used in the development and scale-up production routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: May be utilized in the development of biochemical probes for investigating specific biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects requiring this specific pyrazolopyridine carboxylic acid derivative.

Basic Information

Product Name	6-Cyclopropyl-1-Isopropyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	851288-57-8
Molecular Formula	C13H15N3O2
Molecular Weight	245.28 g/mol
Synonyms	6-Cyclopropyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-1-(1-methylethyl)-; 6-Cyclopropyl-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; CAS 851288-57-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity, identity, and impurity profiles. We support development from non-GMP to GMP-grade material, with quality systems designed to meet the rigorous standards of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Any single impurity ≤1.0%; Total impurities ≤3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.