Description

4-Chloro-2,3-Difluoropyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoropyridine core contributes to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or components for OLEDs and semiconductors.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-2,3-Difluoropyridine
CAS No.	851178-99-9
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	2,3-Difluoro-4-chloropyridine; 4-Chloro-2,3-difluoropyridine; 2,3-Difluoro-4-chloro-pyridine; Pyridine, 4-chloro-2,3-difluoro-; 851178-99-9
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2,3-Difluoropyridine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from GC, HPLC, and NMR analyses, is supplied with each shipment to guarantee traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.