Description

4-Chloro-3,5-Difluoropyridine is a versatile halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the pyridine ring, enabling selective functionalization for creating complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoropyridine core contributes to biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science applications.
• Functional Material Development: Employed in the creation of advanced organic materials, including liquid crystals and electronic chemicals.
• Cross-Coupling Reactions: The chlorine atom is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for carbon-carbon and carbon-heteroatom bond formation.
• Nucleophilic Aromatic Substitution: The fluorine atoms can be selectively displaced by nucleophiles, allowing for precise derivatization of the pyridine ring.

Basic Information

Product Name	4-Chloro-3,5-Difluoropyridine
CAS No.	851178-97-7
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	3,5-Difluoro-4-chloropyridine; 4-Chloro-3,5-difluoropyridine; Pyridine, 4-chloro-3,5-difluoro-; 851178-97-7; 4-Chloro-3,5-difluoro-pyridine; 4-Chloro-3,5-difluoropyridine (C5H2ClF2N); 3,5-Difluoro-4-chloro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.