Description

4-Bromo-2,3,5-trifluoropyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the bromine and fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysts.
• Material Science Research: Building block for developing organic electronic materials, such as charge-transport layers in OLEDs and semiconductors, due to its electron-deficient pyridine core.
• Fluorinated Liquid Crystal Precursor: Intermediate in the production of fluorinated liquid crystals for advanced display technologies.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns requiring precise fluorinated/brominated heterocycles.

Basic Information

Product Name	4-Bromo-2,3,5-trifluoropyridine
CAS No.	851178-96-6
Molecular Formula	C5HBrF3N
Molecular Weight	209.96 g/mol
Synonyms	2,3,5-Trifluoro-4-bromopyridine; 4-Bromo-2,3,5-trifluoropyridine; Pyridine, 4-bromo-2,3,5-trifluoro-; 851178-96-6; 4-Bromo-2,3,5-trifluoro-pyridine; 4-Bromo-2,3,5-trifluorpyridin; BRN 12521647
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3,5-trifluoropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from GC, HPLC, NMR, and MS analyses. Our quality commitment aligns with cGMP principles for advanced intermediates, supporting our customers' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or compatible light-resistant packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥97.0% (Standard Grade)
Purity (GC/HPLC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.