Description

(8-Methyl-2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diazepinedione scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small-molecule drugs, where reliable supply and stringent quality are paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and metabolic disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Used in the final or penultimate steps of manufacturing novel Active Pharmaceutical Ingredients (APIs) with spirocyclic motifs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for pharmaceutical clients.
• Chemical Biology: Employed in the development of chemical probes to study biological pathways and protein functions.

Basic Information

Product Name	(8-Methyl-2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Acetic Acid
CAS No.	851170-87-1
Molecular Formula	C12H16N2O4
Molecular Weight	252.27 g/mol
Synonyms	3-(Carboxymethyl)-8-methyl-1,3-diaza-spiro[4.5]decane-2,4-dione; 1,3-Diaza-spiro[4.5]decane-3-acetic acid, 8-methyl-2,4-dioxo-; 8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]decane-3-acetic acid; Spiro[diazepine-3,1'-cyclopentane]-acetic acid derivative; (8-Methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid; 3-Acetic acid-8-methyl-1,3-diaza-spiro[4.5]decane-2,4-dione
EINECS	Contact for details

Quality Control

Our production of (8-Methyl-2,4-Dioxo-1,3-Diaza-Spiro[4.5]Dec-3-Yl)-Acetic Acid adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up activities. All material is released with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH Q7 guidelines and can provide material suitable for use under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.