Description

(R)-tert-Butyl 1-(6-Bromo-5-Methylpyridin-3-Ylamino)-3-(tert-Butylthio)-1-Oxopropan-2-Ylcarbamate CAS NO 850411-22-2 is a high-purity, chiral organic intermediate featuring a complex molecular architecture with bromo, methylpyridine, and tert-butylthio functional groups. This compound is of critical importance for pharmaceutical research and development, serving as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries engaged in creating new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• API Synthesis: Used in the development and scale-up of complex Active Pharmaceutical Ingredients (APIs), leveraging its specific stereochemistry and functional groups.
• Protease Inhibitor Research: Potential precursor in the development of protease inhibitors due to its peptidomimetic structural features.
• Kinase Inhibitor Development: Serves as a sophisticated scaffold in the discovery of kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Employed in advanced synthetic routes requiring high enantiomeric purity for the construction of complex molecules.

Basic Information

Item	Information
Product Name	(R)-tert-Butyl 1-(6-Bromo-5-Methylpyridin-3-Ylamino)-3-(tert-Butylthio)-1-Oxopropan-2-Ylcarbamate
CAS No.	850411-22-2
Molecular Formula	C19H30BrN3O3S
Molecular Weight	460.43 g/mol
Synonyms	(R)-tert-Butyl (1-((6-bromo-5-methylpyridin-3-yl)amino)-3-((tert-butyl)thio)-1-oxopropan-2-yl)carbamate; (R)-N-(tert-Butoxycarbonyl)-3-(tert-butylthio)-2-((6-bromo-5-methylpyridin-3-yl)amino)propanamide; tert-Butyl N-[(2R)-1-[(6-bromo-5-methyl-3-pyridyl)amino]-3-tert-butylsulfanyl-1-oxopropan-2-yl]carbamate; 850411-22-2; (R)-Boc-3-(t-BuS)-Ala(6-Br-5-Me-3-Py) NH2 derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. For this advanced intermediate, quality is assured through stringent analytical methods including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or Certificate of Analysis. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.