Description

4-[4-(tert-Butyldimethylsilyloxy)Phenyl]Phenylboronic Acid is a high-value, synthetically versatile organoboron building block, primarily used in advanced pharmaceutical and materials science research. Its core value lies in its dual functionality, where the boronic acid group enables key cross-coupling reactions like Suzuki-Miyaura, and the silyl-protected phenol offers a handle for further orthogonal functionalization. This compound is essential for researchers and process chemists in medicinal chemistry, particularly for constructing complex biaryl scaffolds found in active pharmaceutical ingredients (APIs) and for developing novel organic electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates via palladium-catalyzed cross-coupling reactions.
• Medicinal Chemistry Research: Used for constructing biaryl and heterobiaryl core structures prevalent in modern small-molecule therapeutics.
• Materials Science: Serves as a monomer or building block for creating advanced polymers, organic semiconductors, and liquid crystals.
• Chemical Synthesis: Employed in the development of novel ligands, catalysts, and functionalized organic molecules.
• Agrochemical Research: Used in the discovery and synthesis of new active ingredients with complex aromatic architectures.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new chemical spaces in organic synthesis.

Basic Information

Product Name	4-[4-(tert-Butyldimethylsilyloxy)Phenyl]Phenylboronic Acid
CAS No.	850380-91-5
Molecular Formula	C18H25BO3Si
Molecular Weight	328.29 g/mol
Synonyms	[4-(4-Hydroxyphenyl)phenyl]boronic acid tert-butyldimethylsilyl ether; 4'-(tert-Butyldimethylsiloxy)biphenyl-4-boronic acid; [1,1'-Biphenyl]-4-boronic acid, 4'-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 4'-(tert-Butyldimethylsilyloxy)-[1,1'-biphenyl]-4-ylboronic acid; 4-(4-((tert-Butyldimethylsilyl)oxy)phenyl)phenylboronic acid; TBDMS-Protected Biphenyl-4-boronic Acid; 4'-OTBDMS Biphenyl-4-boronic Acid
EINECS	Contact for details

Quality Control

Our 4-[4-(tert-Butyldimethylsilyloxy)Phenyl]Phenylboronic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced material research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.