Description

5-Bromo-2-(2,2,3,3,3-pentafluoropropoxy)pyridine is a high-value fluorinated pyridine derivative, a key building block in advanced organic synthesis. This compound matters for its unique combination of a bromo substituent and a pentafluoropropoxy side chain, offering orthogonal reactivity for precise molecular construction. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity, metabolic stability, and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific fluorinated aromatic components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	5-Bromo-2-(2,2,3,3,3-pentafluoropropoxy)pyridine
CAS No.	850349-84-7
Molecular Formula	C8H4BrF5NO
Molecular Weight	314.02 g/mol
Synonyms	2-(2,2,3,3,3-Pentafluoropropoxy)-5-bromopyridine; 5-Bromo-2-(pentafluoropropoxy)pyridine; Pyridine, 5-bromo-2-(2,2,3,3,3-pentafluoropropoxy)-; 850349-84-7; 5-Bromo-2-(perfluoropropoxy)pyridine; 5-Br-2-PFPP; 5-Bromo-2-(1,1,2,2,2-pentafluoroethoxy)pyridine (isomer check); 5-Bromo-2-O-(2,2,3,3,3-pentafluoropropyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(2,2,3,3,3-pentafluoropropoxy)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and other incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.