Description

(3-Bromo-Phenoxy)-Difluoro-Acetic Acid Ethyl Ester is a high-purity, specialty fluorinated organic building block with the CAS number 850349-28-9. This compound is valued for its unique molecular structure, which incorporates both bromine and fluorine substituents, making it a versatile intermediate for advanced chemical synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring fluorinated or brominated aromatic motifs for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroacetate ester group can be a crucial functional handle.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials that benefit from halogenated aromatic units.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological systems, leveraging the reactivity of the bromine atom for further functionalization.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(3-Bromo-Phenoxy)-Difluoro-Acetic Acid Ethyl Ester
CAS No.	850349-28-9
Molecular Formula	C10H9BrF2O3
Molecular Weight	295.08 g/mol
Synonyms	Ethyl 2-(3-Bromophenoxy)-2,2-difluoroacetate; 2,2-Difluoro-2-(3-bromophenoxy)acetic Acid Ethyl Ester; Ethyl (3-Bromophenoxy)difluoroacetate; Difluoro(3-bromophenoxy)acetic Acid Ethyl Ester; 850349-28-9; AI3-52375; AC1L1U5K; SCHEMBL218064; CTK8C4685; ZINC000005014761
EINECS	Contact for details

Quality Control

Our (3-Bromo-Phenoxy)-Difluoro-Acetic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.