Description

Ethyl trans-1-Boc-4-Hydroxypyrrolidine-3-Carboxylate is a high-purity, protected pyrrolidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex molecules with precise stereochemistry, essential for developing bioactive compounds. This intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel drug candidates, particularly in areas like protease inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other small molecule drugs.
• Peptidomimetics Construction: Used to introduce constrained, stereodefined pyrrolidine motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and drug discovery projects.

Basic Information

Product Name	Ethyl trans-1-Boc-4-Hydroxypyrrolidine-3-Carboxylate
CAS No.	849935-83-7
Molecular Formula	C₁₂H₂₁NO₅
Molecular Weight	259.30 g/mol
Synonyms	trans-1-(tert-Butoxycarbonyl)-4-hydroxy-3-pyrrolidinecarboxylic Acid Ethyl Ester; Ethyl (3R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-3-carboxylate; Ethyl 1-Boc-4-hydroxypyrrolidine-3-carboxylate (trans); 1-Boc-4-hydroxy-3-pyrrolidinecarboxylic acid ethyl ester; 1-N-Boc-4-hydroxy-3-pyrrolidinecarboxylic acid ethyl ester; trans-4-Hydroxy-1-Boc-pyrrolidine-3-carboxylic acid ethyl ester; (3R,4R)-1-Boc-4-hydroxypyrrolidine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl trans-1-Boc-4-Hydroxypyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.