Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[(4-Methylphenyl)Sulfonyl]-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonylated pyrrolopyridine core structure. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted drug candidates, especially those acting on specific enzymatic pathways.
• Kinase Inhibitor Development: Serves as a core scaffold or a functionalized fragment for constructing potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Bioconjugation & Probe Synthesis: The ester and sulfonyl functional groups can be utilized for further chemical modifications to create labeled probes or conjugate molecules for biological studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry for custom synthesis and process development.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[(4-Methylphenyl)Sulfonyl]-, Methyl Ester
CAS No.	849067-95-4
Molecular Formula	C16H14N2O4S
Molecular Weight	330.36 g/mol
Synonyms	Methyl 1-(p-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 1-[(4-Methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, methyl ester; Methyl 1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylate; 849067-95-4; 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-5-methyl carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for pharmaceutical research. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.