Description

1-Pyrrolidinecarboxylic Acid, 2-(1-Hydroxyethyl)-, 1,1-Dimethylethyl Ester, (2R)- is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its stereochemically defined structure, which is critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and production in the pharmaceutical industry, particularly for developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, especially those targeting the central nervous system.
• API Development: Used in research and process chemistry for the development and scale-up of new active pharmaceutical ingredients.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Peptidomimetics: Acts as a constrained proline analog for designing and synthesizing novel peptide-like compounds with enhanced stability.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 2-(1-Hydroxyethyl)-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	848482-37-1
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(2R)-2-(1-Hydroxyethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (2R)-2-(1-hydroxyethyl)pyrrolidine-1-carboxylate; (R)-tert-Butyl 2-(1-hydroxyethyl)pyrrolidine-1-carboxylate; (R)-1-Boc-2-(1-hydroxyethyl)pyrrolidine; (R)-N-Boc-2-(1-hydroxyethyl)pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-2-(1-hydroxyethyl)pyrrolidine; (R)-2-(1-Hydroxyethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, GC, and chiral analysis to guarantee high chemical and enantiomeric purity. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.