Description

1-tert-Butyl 2-Methyl 3,3-Dimethyl-4-Oxopyrrolidine-1,2-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate with a protected dicarboxylate structure. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering precise stereochemistry and functional group compatibility. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and fine chemical industries for creating novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Precursor: Used in the research and development of protease inhibitor libraries for antiviral and anticancer drug discovery.
• Peptidomimetic Scaffold: Serves as a constrained scaffold for designing and synthesizing novel peptidomimetics with enhanced bioavailability and metabolic stability.
• Asymmetric Synthesis: Employed in asymmetric catalytic reactions and chiral pool synthesis due to its defined stereocenters and protective groups.
• Chemical Biology Research: Utilized as a tool compound or a tagged molecular probe for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring high-fidelity, gram to kilogram-scale production under cGMP conditions.

Basic Information

Product Name	1-tert-Butyl 2-Methyl 3,3-Dimethyl-4-Oxopyrrolidine-1,2-Dicarboxylate
CAS No.	848444-88-2
Molecular Formula	C13H21NO5
Molecular Weight	271.31 g/mol
Synonyms	1-(tert-Butyl) 2-Methyl 3,3-Dimethyl-4-oxopyrrolidine-1,2-dicarboxylate; 3,3-Dimethyl-4-oxo-1-pyrrolidinecarboxylic Acid 1,2-Diester with tert-Butyl Methyl Ester; 1-Boc-2-Methyl 3,3-Dimethyl-4-oxopyrrolidine-1,2-dicarboxylate; 1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-3,3-dimethyl-4-oxopyrrolidine; 848444-88-2; tert-Butyl Methyl 3,3-Dimethyl-4-oxopyrrolidine-1,2-dicarboxylate
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 2-Methyl 3,3-Dimethyl-4-Oxopyrrolidine-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements, including ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.