Description

2-Borono-5-Methoxy-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl)Ester is a high-value, advanced pharmaceutical intermediate featuring a unique pyrrolopyridine scaffold with a boronic acid pinacol ester protecting group. This compound matters as a critical building block for the synthesis of complex, biologically active molecules, particularly in targeted drug discovery programs. It is primarily needed by research institutions and pharmaceutical companies engaged in developing kinase inhibitors and other small-molecule therapeutics, where its structure enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality makes it an ideal reagent for palladium-catalyzed carbon-carbon bond formation, a cornerstone of modern medicinal chemistry.
• Chemical Biology Probes: Used in the development of tool compounds for studying enzyme function and cellular signaling pathways.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic systems with potential biological activity.
• Process Chemistry Development: Serves as a starting material for scaling up the production of active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Item	Details
Product Name	2-Borono-5-Methoxy-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl)Ester
CAS No.	848357-95-9
Molecular Formula	C15H19BN2O4
Molecular Weight	302.14 g/mol
Synonyms	5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-boronic acid, 1-(1,1-dimethylethyl) ester; 5-Methoxy-1-(tert-butoxycarbonyl)-1H-pyrrolo[3,2-b]pyridine-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methoxy-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; Boc-Protected 5-Methoxypyrrolopyridine-2-boronic ester
EINECS	Contact for details

Quality Control

Our 2-Borono-5-Methoxy-1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid 1-(1,1-Dimethylethyl)Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.