Description

Pentafluorophenyl Nicotinate CAS NO 848347-44-4 is a high-purity chemical intermediate featuring a reactive pentafluorophenyl ester group. This compound is valued for its role in advanced organic synthesis, particularly in facilitating efficient coupling reactions under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring fluorinated components.
• Peptide & Protein Chemistry: Acts as an efficient acylating agent for modifying amino acids or creating custom peptide conjugates.
• Material Science: Employed in the synthesis of advanced polymers and liquid crystals where fluorinated aromatic groups impart specific properties.
• Cross-coupling Reactions: Serves as a versatile reagent in palladium-catalyzed and other metal-mediated coupling reactions.
• Bioconjugation: Useful for labeling biomolecules such as proteins or oligonucleotides with fluorinated probes or tags.

Basic Information

Product Name	Pentafluorophenyl Nicotinate
CAS No.	848347-44-4
Molecular Formula	C12H4F5NO2
Molecular Weight	289.16 g/mol
Synonyms	Pentafluorophenyl 3-pyridinecarboxylate; Nicotinic Acid Pentafluorophenyl Ester; 3-Pyridinecarboxylic Acid, Pentafluorophenyl Ester; PFP-Nicotinate; PFP Ester of Nicotinic Acid; 2,3,4,5,6-Pentafluorophenyl Nicotinate; Pentafluorophenyl Ester of Nicotinic Acid
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl Nicotinate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its sensitivity to strong alkali and fluoride ions, keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.