Description

Pemafibrate is a selective peroxisome proliferator-activated receptor alpha (PPARα) modulator. This compound is of significant interest for its potent lipid-regulating and anti-inflammatory properties, making it a valuable research chemical. It is primarily utilized by pharmaceutical R&D laboratories and academic institutions engaged in metabolic disease, cardiovascular research, and drug discovery programs.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics for dyslipidemia.
• Biochemical Research: Used as a potent and selective PPARα agonist to study receptor activation pathways, gene expression, and metabolic regulation in in vitro and in vivo models.
• Metabolic Disease Studies: Applied in preclinical research targeting conditions such as hypertriglyceridemia, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD).
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control (QC) testing of pharmaceutical products.
• Academic Research: Utilized in university and institutional labs for fundamental studies on lipid metabolism, inflammation, and cardiovascular biology.

Basic Information

Product Name	Pemafibrate
CAS No.	848259-27-8
Molecular Formula	C23H20ClFO3
Molecular Weight	398.85 g/mol
Synonyms	K-877; Parmodia; Pemafibrate; 2-{4-[(2R)-2-{3-[(4-Chlorophenyl)formamido]phenoxy}butoxy]phenyl}acetic acid; (αR)-α-{4-[(2R)-2-{3-[(4-Chlorobenzoyl)amino]phenoxy}butoxy]phenyl}acetic acid; K 877; K877
EINECS	Contact for details

Quality Control

Our Pemafibrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity research standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.