Description

Pemafibrate (Racemate) is a selective peroxisome proliferator-activated receptor alpha (PPARα) modulator. This compound is of significant interest in pharmaceutical research and development, particularly for its potential role in lipid metabolism regulation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents targeting dyslipidemia and related metabolic disorders.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block or precursor in the synthesis of enantiomerically pure Pemafibrate.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate PPARα receptor pharmacology, signaling pathways, and gene expression effects.
• Metabolic Disease Research: A critical tool for preclinical research into hypertriglyceridemia, non-alcoholic fatty liver disease (NAFLD), and other lipid disorders.
• Formulation Development: Used in the development and testing of various drug delivery systems and dosage forms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	Pemafibrate (Racemate)
CAS No.	848258-31-1
Molecular Formula	C23H20ClFO4
Molecular Weight	414.85 g/mol
Synonyms	Pemafibrate Racemic Mixture; K-877 Racemate; 2-{4-[(2R/S)-2-{3-[(4-Chlorophenyl)formamido]methyl}phenoxy]-2-methylpropanoic acid}oxy-4-fluorobenzoic acid; K 877 (Racemic); PPARα Modulator K-877 Racemate; [(4-Chlorophenyl)carbamoyl]methyl 2-((4-fluorophenoxy)methyl)-2-methylpropanoate Racemate; (R/S)-Pemafibrate
EINECS	Contact for details

Quality Control

Our Pemafibrate (Racemate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric composition, and identity confirmation by IR and MS. We provide Certificates of Analysis (COA) with detailed results for all critical quality attributes, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	Racemic mixture (50:50 ratio)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.