Description

2-Bromo-3-Trimethylsilanyl-Isonicotinic Acid Methyl Ester is a high-value, organosilicon-protected pyridine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its molecular architecture, featuring both a bromine substituent and a trimethylsilyl (TMS) protecting group, makes it a versatile building block for constructing complex heterocyclic frameworks. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Protecting Group Chemistry: The trimethylsilyl group can be selectively removed under mild conditions, allowing for sequential functionalization of the pyridine core.
• Ligand Synthesis: Used to prepare sophisticated nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Bromo-3-Trimethylsilanyl-Isonicotinic Acid Methyl Ester
CAS No.	848243-28-7
Molecular Formula	C10H14BrNO2Si
Molecular Weight	288.22 g/mol
Synonyms	Methyl 2-bromo-3-(trimethylsilyl)isonicotinate; 2-Bromo-3-(trimethylsilyl)isonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 2-bromo-3-(trimethylsilyl)-, methyl ester; Isonicotinic acid, 2-bromo-3-(trimethylsilyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-3-Trimethylsilanyl-Isonicotinic Acid Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.