Description

tert-Butyl 6-Chloro-5-Hydroxynicotinate is a high-purity, versatile chemical intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring a protected carboxylic acid and reactive halogen and hydroxyl groups, makes it a critical building block for the development of complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for constructing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly for developing nicotinic acid derivatives and other nitrogen-containing heterocycles with potential therapeutic activity.
• Agrochemical Synthesis: Serves as a foundational building block for creating novel pesticides, herbicides, and fungicides, leveraging its halogen and hydroxyl functional groups for further chemical modifications.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for constructing complex molecular architectures, studying reaction mechanisms, and developing new synthetic methodologies.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Precursor: Potential use in the development of advanced organic materials, such as polymers or liquid crystals, where its specific substitution pattern can impart desired properties.

Basic Information

Item	Details
Product Name	tert-Butyl 6-Chloro-5-Hydroxynicotinate
CAS No.	847943-54-8
Molecular Formula	C10H12ClNO3
Molecular Weight	229.66 g/mol
Synonyms	6-Chloro-5-hydroxy-3-pyridinecarboxylic acid tert-butyl ester; tert-Butyl 6-chloro-5-hydroxy-3-pyridinecarboxylate; 5-Hydroxy-6-chloronicotinic acid tert-butyl ester; 3-Pyridinecarboxylic acid, 6-chloro-5-hydroxy-, 1,1-dimethylethyl ester; 6-Chloro-5-hydroxynicotinic acid tert-butyl ester; tert-Butyl 6-chloro-5-hydroxypyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Chloro-5-Hydroxynicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.