Description

3-Chloro-5-(Chloromethyl)Pyridine is a versatile and highly functionalized pyridine derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its dual reactive sites—the chloromethyl group and the chlorine atom on the aromatic ring—make it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of functional polymers and organic electronic materials due to its aromatic and halogenated structure.
• Cross-Coupling Reactions: The chlorine substituents are amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Research: A valuable scaffold in medicinal and combinatorial chemistry for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-Chloro-5-(Chloromethyl)Pyridine
CAS No.	847737-51-3
Molecular Formula	C6H5Cl2N
Molecular Weight	162.02 g/mol
Synonyms	5-(Chloromethyl)-3-chloropyridine; 3-Chloro-5-chloromethylpyridine; Pyridine, 3-chloro-5-(chloromethyl)-; 3,5-Bis(chloromethyl)pyridine (incorrect but common misnomer); 3-Chloro-5-(chloromethyl)pyridine; 847737-51-3; 3-Chloro-5-chloromethyl-pyridine
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Chloromethyl)Pyridine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic (HPLC, GC) and spectroscopic (NMR, IR) techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting cGMP and ISO 9001 quality management principles for industrial and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.