Description

Methyl2-Chloro-5-Fluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This intermediate is essential for research chemists and process development scientists working on novel active ingredients, where precise chemical functionality is paramount.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated heterocyclic cores.
• Material Science Research: Acts as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities.
• Academic & Industrial R&D: Utilized in discovery chemistry for constructing diverse compound libraries and exploring new chemical spaces.

Basic Information

Product Name	Methyl2-Chloro-5-Fluoronicotinate
CAS No.	847729-27-5
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 2-chloro-5-fluoropyridine-3-carboxylate; 2-Chloro-5-fluoronicotinic acid methyl ester; 3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, methyl ester; Methyl 2-chloro-5-fluoro-3-pyridinecarboxylate; 847729-27-5; Methyl 2-chloro-5-fluoronicotinate; 2-Chloro-5-fluoro-3-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl2-Chloro-5-Fluoronicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.