Description

tert-Butyl 4-(Trifluoromethyl)-4-((trimethylsilyl)oxy)piperidine-1-carboxylate is a high-value, protected piperidine derivative featuring both trifluoromethyl and silyl ether functional groups. This compound is a critical advanced intermediate in modern pharmaceutical synthesis, enabling the efficient construction of complex bioactive molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science Precursor: Potential use in synthesizing specialty monomers or ligands for advanced polymeric materials and catalysts.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	tert-Butyl 4-(Trifluoromethyl)-4-((Trimethylsilyl)Oxy)Piperidine-1-Carboxylate
CAS No.	847591-35-9
Molecular Formula	C14H26F3NO3Si
Molecular Weight	341.45 g/mol
Synonyms	1-Boc-4-(trifluoromethyl)-4-(trimethylsilyloxy)piperidine; 1-(tert-Butoxycarbonyl)-4-(trifluoromethyl)-4-(trimethylsilyloxy)piperidine; 4-(Trifluoromethyl)-4-(trimethylsilyloxy)piperidine-1-carboxylic acid tert-butyl ester; 4-(Trimethylsilyloxy)-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(trimethylsilyloxy)-4-(trifluoromethyl)piperidine-1-carboxylate; 1-Boc-4-trifluoromethyl-4-(TMS-oxy)piperidine; 4-(TMS-oxy)-4-(trifluoromethyl)-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(Trifluoromethyl)-4-((trimethylsilyl)oxy)piperidine-1-carboxylate adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support our clients' regulatory needs with comprehensive documentation for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.