Description

(E)-4-(4-Fluoro-Phenyl)-1-Imidazol-1-Yl-2-Pyridin-3-Yl-But-3-En-2-Ol is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate, enabling the construction of complex molecules with precise stereochemistry for targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries working on novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides where specific enantiomeric purity is crucial for efficacy and environmental safety.
• Chemical Biology Probe: Acts as a scaffold or ligand in the design of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Catalysis: Employed as a precursor or a ligand in the development of new asymmetric catalytic systems for green chemistry applications.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, complex organic molecules with defined stereocenters.

Basic Information

Product Name	(E)-4-(4-Fluoro-Phenyl)-1-Imidazol-1-Yl-2-Pyridin-3-Yl-But-3-En-2-Ol
CAS No.	847570-47-2
Molecular Formula	C22H18FN3O
Molecular Weight	359.40 g/mol
Synonyms	(E)-4-(4-Fluorophenyl)-1-(1H-imidazol-1-yl)-2-(pyridin-3-yl)but-3-en-2-ol; 4-(4-Fluorophenyl)-1-imidazol-1-yl-2-pyridin-3-yl-but-3-en-2-ol, (E)-; (E)-4-(4-Fluorophenyl)-1-(imidazol-1-yl)-2-(3-pyridinyl)-3-buten-2-ol; CAS 847570-47-2; Fluorophenyl-imidazolyl-pyridinyl-buten-ol intermediate
EINECS	Contact for details

Quality Control

Every batch of (E)-4-(4-Fluoro-Phenyl)-1-Imidazol-1-Yl-2-Pyridin-3-Yl-But-3-En-2-Ol is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research specifications, with comprehensive testing for chiral purity (enantiomeric excess) being a key differentiator. Certificates of Analysis (COA) documenting all critical parameters are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.