Description

4-Pyridinecarbonitrile, 3-Hydroxy-2-Methyl-5-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block characterized by its pyridine core, nitrile group, and trifluoromethyl substitution. This compound matters for its unique molecular architecture, which enables the synthesis of complex molecules with tailored properties, particularly in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, photoaffinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Pyridinecarbonitrile, 3-Hydroxy-2-Methyl-5-(Trifluoromethyl)-
CAS No.	846055-93-4
Molecular Formula	C8H5F3N2O
Molecular Weight	202.14 g/mol
Synonyms	3-Hydroxy-2-methyl-5-(trifluoromethyl)isonicotinonitrile; 3-Hydroxy-2-methyl-5-(trifluoromethyl)pyridine-4-carbonitrile; 5-(Trifluoromethyl)-3-hydroxy-2-methyl-4-pyridinecarbonitrile; 4-Cyano-3-hydroxy-2-methyl-5-(trifluoromethyl)pyridine; 2-Methyl-3-hydroxy-5-trifluoromethyl-4-cyanopyridine; 846055-93-4 (CAS Name based); TFMP Derivative Building Block
EINECS	Contact for details

Quality Control

Our production of 4-Pyridinecarbonitrile, 3-Hydroxy-2-Methyl-5-(Trifluoromethyl)- adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to cGMP principles and compliance with REACH regulations ensures a reliable supply for global research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.