Description

4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyridine-3-Carbonitrile is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both a tetrahydropyridine core and a trifluoromethyl group, makes it a critical intermediate for developing novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the design and synthesis of novel pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and metabolic stability.
• Material Science Research: Acts as a precursor for specialty chemicals and functional materials, including liquid crystals and organic semiconductors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to introduce the pharmacologically beneficial CF3 moiety.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic Research: Utilized in university and institutional labs for methodological development in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyridine-3-Carbonitrile
CAS No.	845866-48-0
Molecular Formula	C7H7F3N2
Molecular Weight	176.14 g/mol
Synonyms	3-Cyano-4-(trifluoromethyl)-1,4,5,6-tetrahydropyridine; 4-(Trifluoromethyl)-3-cyano-1,4,5,6-tetrahydropyridine; 1,4,5,6-Tetrahydro-4-(trifluoromethyl)-3-pyridinecarbonitrile; 4-Trifluoromethyl-1,4,5,6-tetrahydropyridine-3-carbonitrile; 845866-48-0; 4-(Trifluoromethyl)-δ³-piperideine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1,4,5,6-Tetrahydropyridine-3-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.