Description

Pyridine, 5-Bromo-2-(Difluoromethyl)- is a specialized halogenated pyridine derivative that serves as a high-value synthetic intermediate. This compound is critical for introducing both bromine and difluoromethyl functional groups into target molecules, enabling precise structural modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in medicinal chemistry for creating molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the difluoromethyl group's unique physicochemical properties.
• Material Science Research: Acts as a precursor for creating functionalized ligands, organic semiconductors, or specialty polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Fluorine Chemistry Exploration: Serves as a valuable reagent in academic and industrial labs focused on incorporating fluorine atoms into organic frameworks to study structure-activity relationships.

Basic Information

Product Name	Pyridine, 5-Bromo-2-(Difluoromethyl)-
CAS No.	845827-13-6
Molecular Formula	C7H4BrF2N
Molecular Weight	220.02 g/mol
Synonyms	5-Bromo-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-5-bromopyridine; 5-Bromo-2-difluoromethylpyridine; Pyridine, 2-(difluoromethyl)-5-bromo-; 845827-13-6
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-(Difluoromethyl)pyridine is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our standard quality commitment includes comprehensive analytical characterization using techniques such as NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.