Description

1-(Trimethylsilyl)-3-Chloro-5-Fluorobenzene is a high-purity organosilicon intermediate featuring a unique halogenated aromatic structure. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in the development of complex molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogen and silicon functionality.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for creating complex biaryl structures.
• Organic Synthesis Building Block: Utilized in laboratory-scale and pilot-scale synthesis to introduce the trimethylsilyl-protected phenol moiety into target molecules.
• Chemical Research & Development: Essential for academic and industrial research exploring new synthetic methodologies and organosilicon chemistry.

Basic Information

Product Name	1-(Trimethylsilyl)-3-Chloro-5-Fluorobenzene
CAS No.	845823-23-6
Molecular Formula	C9H12ClFSi
Molecular Weight	202.73 g/mol
Synonyms	3-Chloro-5-fluoro-1-(trimethylsilyl)benzene; 1-Chloro-3-fluoro-5-(trimethylsilyl)benzene; (3-Chloro-5-fluorophenyl)trimethylsilane; Benzene, 1-chloro-3-fluoro-5-(trimethylsilyl)-; TMS-Protected 3-Chloro-5-Fluorobenzene
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-3-Chloro-5-Fluorobenzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized by advanced analytical techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.