Description

1-(Trimethylsilyl)-4-Chloro-3-Fluorobenzene is a high-value organosilicon intermediate featuring a halogenated aromatic ring system. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the introduction of both a silyl protecting group and halogen substituents for further functionalization. Pharmaceutical, agrochemical, and advanced materials researchers need this chemical for developing active ingredients and novel polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the chloro-fluoro-phenyl group is a critical pharmacophore.
• Material Science Research: Serves as a precursor for silicon-containing polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive chlorine atom.
• Protecting Group Chemistry: The trimethylsilyl group can be used to protect reactive sites during multi-step synthetic sequences.
• Liquid Crystal & OLED Development: Utilized in the research and production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials.

Basic Information

Product Name	1-(Trimethylsilyl)-4-Chloro-3-Fluorobenzene
CAS No.	845823-22-5
Molecular Formula	C9H12ClFSi
Molecular Weight	202.73 g/mol
Synonyms	4-Chloro-3-fluoro-1-(trimethylsilyl)benzene; (4-Chloro-3-fluorophenyl)trimethylsilane; Benzene, 1-chloro-4-fluoro-2-(trimethylsilyl)-; 1-Chloro-4-fluoro-2-(trimethylsilyl)benzene; TMS-Chlorofluorobenzene; Trimethyl(4-chloro-3-fluorophenyl)silane
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-4-Chloro-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.