Description

1-(Trimethylsilyl)-4-Fluoro-3-Methylbenzene is a high-purity organosilicon intermediate featuring a fluorinated aromatic ring system. This compound is valued for its role as a versatile building block in advanced organic synthesis, where its trimethylsilyl group offers protective and directing properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecules and novel functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials for electronic displays.
• Advanced Polymer Chemistry: Incorporated into specialty polymers and resins to modify thermal stability, solubility, and surface properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.
• Protecting Group Strategy: The trimethylsilyl moiety can be used as a temporary protecting group for aromatic systems in multi-step synthetic sequences.

Basic Information

Product Name	1-(Trimethylsilyl)-4-Fluoro-3-Methylbenzene
CAS No.	845823-18-9
Molecular Formula	C10H15FSi
Molecular Weight	182.31 g/mol
Synonyms	4-Fluoro-3-methyl-1-(trimethylsilyl)benzene; (4-Fluoro-3-methylphenyl)trimethylsilane; 1-Fluoro-2-methyl-4-(trimethylsilyl)benzene; 4-Fluoro-m-tolyltrimethylsilane; Trimethyl(4-fluoro-3-methylphenyl)silane; Benzene, 1-fluoro-2-methyl-4-(trimethylsilyl)-; TMS-4-Fluoro-3-methylbenzene
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-4-Fluoro-3-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are available upon request for quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.