Description

1-(Trimethylsilyl)-3-Fluoro-4-Methylbenzene is a high-purity organosilicon intermediate featuring a strategically functionalized aromatic ring. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the introduction of both silyl-protecting groups and fluorine atoms into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive trimethylsilyl group.
• Protecting Group Chemistry: Utilized in multi-step synthetic routes where the trimethylsilyl moiety acts as a temporary protecting group for hydroxyl or other sensitive functionalities.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring the effects of fluorination on molecular properties.

Basic Information

Product Name	1-(Trimethylsilyl)-3-Fluoro-4-Methylbenzene
CAS No.	845823-16-7
Molecular Formula	C10H15FSi
Molecular Weight	182.31 g/mol
Synonyms	3-Fluoro-4-methylphenyltrimethylsilane; (3-Fluoro-4-methylphenyl)trimethylsilane; Trimethyl(3-fluoro-4-methylphenyl)silane; 3-Fluoro-4-methyl-1-(trimethylsilyl)benzene; 1-Fluoro-2-methyl-5-(trimethylsilyl)benzene; TMS-3-Fluoro-4-methylbenzene; CAS 845823-16-7
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3-Fluoro-4-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Assay (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.