Description

Lexatumumab is a fully human agonistic monoclonal antibody targeting the TRAIL receptor-2 (DR5). This product is a critical research-grade biological reagent for advancing oncology and immunology studies. It is essential for scientists and pharmaceutical developers investigating apoptosis pathways and developing novel cancer therapeutics. The compound is supplied as a high-purity, lyophilized powder to ensure stability and performance in demanding research and pre-clinical applications.

Application

• Apoptosis Research: Used as a key tool to study the extrinsic apoptosis pathway mediated by death receptor 5 (DR5/TRAIL-R2).
• Cancer Cell Line Studies: Employed in in vitro assays to evaluate the sensitivity of various tumor cell lines to DR5-mediated cell death.
• Pre-clinical Therapeutic Development: Serves as a reference standard or active component in the development and screening of novel TRAIL-based cancer therapies.
• Mechanism of Action (MoA) Studies: Utilized to elucidate signaling cascades and resistance mechanisms associated with DR5 activation.
• Combination Therapy Research: Investigated in conjunction with chemotherapeutic agents or other targeted therapies to assess synergistic anti-tumor effects.
• Biomarker Discovery: Aids in research aimed at identifying predictive biomarkers for patient response to DR5-targeting agents.

Basic Information

Product Name	Lexatumumab
CAS No.	845816-02-6
Molecular Formula	Data on file
Molecular Weight	~145 kDa
Synonyms	HGS-ETR2; Anti-TRAIL-R2 mAb; Anti-DR5 Agonistic Antibody; TRAIL Receptor-2 Agonistic Antibody; Death Receptor 5 Agonist; ETR2; Human Anti-TRAILR2 Agonistic Monoclonal Antibody
EINECS	Not listed / Contact for details

Quality Control

Our Lexatumumab is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to a comprehensive suite of analytical tests, including SDS-PAGE, SEC-HPLC for purity and aggregation analysis, endotoxin testing, and functional activity assays (e.g., cell-based apoptosis assays). A Certificate of Analysis (COA) detailing purity, concentration, and specific activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, the lyophilized powder should be kept at -20°C or below. Once reconstituted, aliquot and store at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Purity (SEC-HPLC)	> 90% (Monomer)
Endotoxin Level	< 1.0 EU/mg
Protein Concentration	≥ 1.0 mg/mL (upon reconstitution)
Biological Activity (Cell-based Assay)	EC50 provided on COA
Identification (Mass Spec)	Consistent with theoretical mass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.